Spatial Distribution of Economic Activities in Local Labour Market Areas: the Case of Italy

In recent years, a large number of studies investigated the spatial distribution of economic activities in Western Europe by means of various measures of geographical concentration. The fundamental problem with the indices currently used in the literature is that they do not take explicitly into account the spatial structure of the data, and as a result the same degree of concentration is compatible with very different localization schemes. In the present work we present an analysis which combines the information provided by the standard measure of concentration of Ellison and Glaeser together with the measure of spatial correlation introduced by Moran. The problem known in geography as MAUP is here addressed by considering both administrative and functional regions in the empirical analyses. Data on employment and plant size for the years 1991 and 2001 are used to identify sectoral location patterns in Italy and The Netherlands within the manufacturing and service sectors.

The Spatial Distribution of Economic Activities in Italy

Existing indices measuring the spatial distribution of economic activity such as the Krugman Specialisation Index, the Hirschmann-Herfindahl index and the Ellison-Glaeser index typically do not take into account the spatial structure of the data. In this paper, we first consider traditional measures of geographical concentration, and subsequently extend the analysis to take spatial dependence into account. Using data for Italy for the years 1991 and 2001, we apply exploratory spatial data analysis to identify sectoral location patterns in both the manufacturing industry as well as in services. We find that large differences prevail in the geographical concentration of production across sectors. The results of the exploratory spatial data analysis reveal the existence of well- defined clusters of economic activities

Communicating corporate social responsibility to involve stakeholders. The case of employer branding for university students

La responsabilità sociale d'impresa (o Corporate Social Responsibility, CSR) è uno strumento efficace di marketing e la sua efficacia è mediata dalla modalità con cui le aziende comunicano le proprie attività di CSR agli stakeholder. La ricerca si propone di valutare l'effetto di cinque strategie di comunicazione della CSR, ordinate secondo un livello crescente di coinvolgimento degli stakeholder, sull'Employer Branding (EB) di un'azienda ipotetica. Attraverso la distribuzione di cinque varianti di un opuscolo, l’azienda è stata presentata a due campioni di studenti universitari (n=167; n=112) in cinque diversi scenari comunicativi della CSR. È stato somministrato un questionario con scale che misurano l’attrattività dell'azienda, il prestigio percepito dell'azienda, la disponibilità dei soggetti a entrare in contatto con l'azienda e l’impegno prospettico sul lavoro. È stata anche indagata la percezione della brand personality e della comunicazione della CSR. Le analisi confermano che tutti e cinque gli scenari sono caratterizzati da alti livelli delle dimensioni dell’EB, però lo specifico dialogo di CSR adottato può generare differenti percezioni della brand personality dell'azienda.Corporate Social Responsibility (CRS) is an effective marketing lever, and its effectiveness is mediated by the strategies companies use to communicate their CRS activities to stakeholders. The present research aims at assessing the effect of five CSR communicative strategies, ranked according to an increasing involvement level of stakeholders, on a fictional company’s Employer Branding (EB). The company was presented to two samples of university students (n=167; n=112) via the administration of five different versions of a brochure, corresponding to five different communicative scenarios of CSR. A self-report questionnaire was administrated, with scales measuring the company’s attractiveness, perceived prestige, intention to contact the company, and prospective engagement, as well as the company’s perceived brand personality and CSR communication. Analyses report high levels of the EB dimensions in all five communicative scenarios, which however produce different perceptions of the company’s brand personality

European university funding and financial autonomy. A study on the degree of diversification of university budget and the share of competitive funding

The main objective of this report is to investigate the structure of the budget in a sample of research-active European universities and to analyse to what extent the level of financial autonomy effects the diversification of their budget and the amount of competitive funding they receive. The study covers 200 research-active universities from 33 European Research Area (ERA) countries (27 Member States and Croatia, Iceland, Israel, Norway, Switzerland and Turkey) within the framework of the 'European Observatory of Research-Active Universities and National Public Research Funding Agencies' (UniObs). The criteria followed to select the list of universities in the sample are based on research performance and country representativeness. The main findings of the study are as follows: ¿Looking at the general budget, 70 % of the total university income comes from government allocations. Sources from private companies represent about 6 %, around 3 % comes from non-profit sectors and approximately 2 % is from abroad. The remaining 19 % belongs to a residual category 'Other'. ¿Considering only public funding coming from government (national and regional) we observe that, on average, about 20 % is assigned on a competitive basis, with UK institutions and, in general, technological universities having the highest shares of competitive funds. ¿We observe large within-country variability in the shares of government competitive funds, which could be attributed to the strategic behaviour of single institutions in acquiring funds or to their ability to compete successfully against other institutions. Examples of these are the University of Cambridge in the UK, the University of Karlsruhe in Germany, the University of Florence in Italy, and the universities of Leiden and Wageningen in the Netherlands. ¿Most institutions with highly diversified budgets are located in the UK. ¿University research budgets vary considerably between institutions. Research funds coming from regional authorities are considered important for institutions operating in countries with a more decentralised government structure such as Belgium, Germany or Spain. ¿Institutions that declare to be completely autonomous are the ones that have the most diversified budget. ¿The share of competitive-based government funds increases with increasing levels of institutional financial autonomy. ¿National or institutional settings which do not allow universities to act in a fully financially autonomous way appear to be less likely to produce a real change.JRC.DDG.J.3-Knowledge for Growt

Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle.

BACKGROUND AND PURPOSE: Human malignant hyperthermia (MH) syndrome is induced by volatile anaesthetics and involves increased levels of cystathionine β-synthase (CBS)-derived H2 S within skeletal muscle. This increase contributes to skeletal muscle hypercontractility. Kv 7 channels, expressed in skeletal muscle, may be a molecular target for H2 S. Here, we have investigated the role of Kv 7 channels in MH. EXPERIMENTAL APPROACH: Skeletal muscle biopsies were obtained from MH-susceptible (MHS) and MH-negative (MHN) patients. Immunohistochemistry, RT-PCR, Western blot, and in vitro contracture test (IVCT) were carried out. Development and characterization of primary human skeletal muscle cells (PHSKMC) and evaluation of cell membrane potential were also performed. The persulfidation state of Kv 7 channels and polysulfide levels were measured. KEY RESULTS: Kv 7 channels were similarly expressed in MHN and MHS biopsies. The IVCT revealed an anomalous contractility of MHS biopsies following exposure to the Kv 7 channel opener retigabine. Incubation of negative biopsies with NaHS, prior to retigabine addition, led to an MHS-like positive response. MHS-derived PHSKMC challenged with retigabine showed a paradoxical depolarizing effect, compared with the canonical hyperpolarizing effect. CBS expression and activity were increased in MHS biopsies, resulting in a major polysulfide bioavailability. Persulfidation of Kv 7.4 channels was significantly higher in MHS than in MHN biopsies. CONCLUSIONS AND IMPLICATIONS: In skeletal muscle of MHS patients, CBS-derived H2 S induced persulfidation of Kv 7 channels. This post-translational modification switches the hyperpolarizing activity into depolarizing. This mechanism can contribute to the pathological skeletal muscle hypercontractility typical of MH syndrome

Monitoring and predicting the risk of violence in residential facilities. No difference between patients with history or with no history of violence

none34noopende Girolamo, Giovanni; Buizza, Chiara; Sisti, Davide; Ferrari, Clarissa; Bulgari, Viola; Iozzino, Laura; Boero, Maria Elena; Cristiano, Giuseppe; De Francesco, Alessandra; Giobbio, Gian Marco; Maggi, Paolo; Rossi, Giuseppe; Segalini, Beatrice; Candini, Valentina; Andreose, Suor; Basso, Pasquale; Beneduce, Rossella; Bertolotti, Pietro; Braida, Vanda; Bonelli, Marina; Bongiorno, Fanny; Bussi, Riccardo; Castagno, Elisa; Dominicis, Fabio; Ghersi, Loredana; Greppo, Stefania; Sodano, Alessandro Jaretti; Leporatti, Massimo; Presti, Eleonora Lo; Milone, Valeria; Panigada, Fausto; Pasquadibisceglie, Livia; Rigamonti, Danilo; Rillosi, Lucianade Girolamo, Giovanni; Buizza, Chiara; Sisti, Davide; Ferrari, Clarissa; Bulgari, Viola; Iozzino, Laura; Boero, Maria Elena; Cristiano, Giuseppe; De Francesco, Alessandra; Giobbio, Gian Marco; Maggi, Paolo; Rossi, Giuseppe; Segalini, Beatrice; Candini, Valentina; Andreose, Suor; Basso, Pasquale; Beneduce, Rossella; Bertolotti, Pietro; Braida, Vanda; Bonelli, Marina; Bongiorno, Fanny; Bussi, Riccardo; Castagno, Elisa; Dominicis, Fabio; Ghersi, Loredana; Greppo, Stefania; Sodano, Alessandro Jaretti; Leporatti, Massimo; Presti, Eleonora Lo; Milone, Valeria; Panigada, Fausto; Pasquadibisceglie, Livia; Rigamonti, Danilo; Rillosi, Lucian

Scandinavian Higher Education Governance – Pursuing Similar Goals through Different Organizational Arrangements

Under embargo until: 2022-02-03The differences and similarities among the three Scandinavian countries, Denmark, Norway, and Sweden have been discussed by social scientists on several occasions. Focusing on higher education (HE) governance systems, this paper raises three questions. (1) What are the differences and similarities among the three countries? (2) How can the similarities and differences be explained? (3) Are the similarities strong enough to justify the common label of a Scandinavian model of HE governance? The three HE governance systems are briefly described and compared. They are then analyzed as, respectively, outcomes of partisan politics or politico-administrative regimes. The paper argues that similarities such as publicness, massive investments, and emphasis on access are best explained in terms of partisan politics, while the variation in governance arrangements can best be explained by path dependencies following choices made at critical junctures within similar politicoadministrative regimes.acceptedVersio

A meta-analysis of the investment-uncertainty relationship

In this article we use meta-analysis to investigate the investment-uncertainty relationship. We focus on the direction and statistical significance of empirical estimates. Specifically, we estimate an ordered probit model and transform the estimated coefficients into marginal effects to reflect the changes in the probability of finding a significantly negative estimate, an insignificant estimate, or a significantly positive estimate. Exploratory data analysis shows that there is little empirical evidence for a positive relationship. The regression results suggest that the source of uncertainty, the level of data aggregation, the underlying model specification, and differences between short- and long-run effects are important sources of variation in study outcomes. These findings are, by and large, robust to the introduction of a trend variable to capture publication trends in the literature. The probability of finding a significantly negative relationship is higher in more recently published studies. JEL Classification: D21, D80, E22 1